2021 NFL Week 1 Point Spreads from Las Vegas

Westgate SuperBook’s NFL Week 1 Lines

Kickoff for the 2021 NFL season will be here before you know it, and the Westgate Las Vegas SuperBook has just released their opening round of NFL Week 1 point spreads and totals. The Tampa Bay Bucs will host the regular season opener on Thursday, September 9 as a -6.5 home favorite against the visiting Dallas Cowboys. The Los Angeles Rams are a 7-point home favorite over the Chicago Bears in the Sunday night game, and the Baltimore Ravens have opened as a 4-point road favorite at Las Vegas in the Monday night game.

Stay on top of the latest NFL updates directly from Las Vegas!

Did you keep up with the coaching carrousel during the offseason? Here’s what you may have missed…

  • Former Tennessee Titans offensive coordinator Arthur Smith has replaced Dan Quinn and Raheem Morris in Atlanta.
  • The Detroit Lions have hired Dan Campbell, who will be getting his second run as a head coach after a brief interim stint in Miami in 2015.
  • Urban Meyer finally made the jump to the NFL replacing Doug Marrone in Jacksonville.
  • Former Rams’ defensive coordinator Brandon Staley is staying in Los Angeles, but as the new head coach of the Chargers.
  • Former San Francisco 49ers’ defensive coordinator Robert Saleh will get his first head coaching gig with the New York Jets.
  • Offensive mind Nick Sirianni has replaced Doug Pederson with the Philadelphia Eagles.
  • Houston’s David Culley Culley is the oldest (65 years old) first-time head coach in NFL history.

NFL Week 1 Lines as of Tuesday, May 25

NFL Week 1 Dates Point SpreadsTotals
Thurs Sept 9 at 8pm ETTampa Bay Bucs -6.5 vs Dallas Cowboys52
Sun Sept 12 at 1pm ETBuffalo Bills -6 vs Pittsburgh Steelers49.5
Sun Sept 12 at 1pm ETCarolina Panthers -4.5 vs NY Jets43
Sun Sept 12 at 1pm ETJacksonville Jaguars -3 at Houston Texans45.5
Sun Sept 12 at 1pm ETTennessee Titans -2.5 vs Arizona Cardinals51
Sun Sept 12 at 1pm ETLA Chargers -1.5 at Washington Football44.5
Sun Sept 12 at 1pm ETAtlanta Falcons -3.5 vs Philadelphia Eagles47.5
Sun Sept 12 at 1pm ETIndianapolis Colts -3 vs Seattle Seahawks52
Sun Sept 12 at 1pm ETMinnesota Vikings -3 at Cincinnati Bengals48
Sun Sept 12 at 1pm ETSF 49ers -7.5 at Detroit Lions46
Sun Sept 12 at 4pm ETKC Chiefs -6.5 vs Cleveland Browns53
Sun Sept 12 at 4pm ETNE Patriots -2.5 vs Miami Dolphins45
Sun Sept 12 at 4pm ETDenver Broncos -1 at NY Giants42.5
Sun Sept 12 at 4pm ETNew Orleans Saints -3 vs GB Packers50.5
Sun Sept 12 at 8pm ETLA Rams -7 vs Chicago Bears44.5
Mon Sept 13 at 8pm ETBaltimore Ravens -4 at LV Raiders51

NFL Point Spreads for the Entire Season

The Westgate Las Vegas SuperBook has also released their opening point spreads for every game of the 2021-22 NFL season. That’s right: Point spreads AND totals for all 272 regular-season games. In the game that everyone has circled, the Buccaneers have opened as a -3.5 road favorite at New England in Tom Brady’s return to Foxboro in Week 4. Other notable point spreads for the 2021-22 NFL season:

  • The Jacksonville Jaguars have opened as 3-point road favorites in Houston in Week 1, but Urban Meyer and Trevor Lawrence have been installed as small home underdogs in their home debut: Denver -1.5 at Jacksonville in Week 2.
  • Speaking of Houston: The Texans have opened as a double-digit underdog in five games this season: +13.5 at Cleveland; +14 at Buffalo; +11.5 at Indianapolis; +10.5 at Arizona; and +13.5 at San Francisco.
  • There are two games scheduled for London this year: Atlanta Falcons -3 vs New York Jets in Week 5, and Miami Dolphins -1.5 vs Jacksonville Jaguars in Week 6.
  • This year’s Thanksgiving games feature Chicago as a 3-point road favorite at Detroit; Dallas as a -5.5 home favorite over the Raiders; and Buffalo as a -1.5 road favorite in New Orleans in the nightcap.

NFL Season Win Totals from Las Vegas

Last, but certainly not least: The Westgate Las Vegas SuperBook has also released their opening round of NFL regular season win totals for the 2021-22 season. The Kansas City Chiefs have opened with the highest win total on the board at 12.5 (-110 each way), followed by their Super Bowl counterparts from Tampa Bay at 11.5 (over -130 / under +110). Remember, the 2021-22 NFL season will be the first with 17 regular season games. With Deshaun Watson’s status in jeopardy, the Houston Texans have opened with the lowest total on the board at 4 wins (over EV / under -120).

WagerTalk’s Live Odds Screen

Since the conclusion of last season’s Super Bowl, WagerTalk has continued to improve and enhance our Live Odds screen. Bettors can view the up-to-the-minute odds from a variety of offshore and Vegas-based sports books. Color-coded alerts will let you know when and how a line has moved. Click on the individual cells to view a line history at each sports book. Interested in knowing what a point spread was on a previous game? Use the “archive” feature to find a previous matchup. View real-time odds on nearly every point spread market: Full games, first halves, first quarters, team totals and moneylines.

WagerTalk's Live Odds Screen

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NFL Opening Line Report

Join Sportsmemo’s Drew Martin and Teddy Covers for the Opening Line Report every Monday afternoon as we prepare for the 2021-22 NFL season. From division odds to regular season win totals to Super Bowl futures, Drew and Teddy are locked in for the NFL offseason betting market.


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