NFC West Week 1 Preview: Arizona Cardinals at San Francisco 49ers

San Francisco vs. Arizona Betting Preview

Will the San Francisco 49ers fall victim to the Super Bowl hangover? The defending NFC champs have a nice test in Week 1 against the visiting Arizona Cardinals. Arizona is 4-0-1 against the spread in the last five meetings in this series. Tune in as the WagerTalk TV crew offers their San Francisco vs. Arizona preview, in addition to other NFL Week 1 predictions for this upcoming weekend.

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Event: (473) Arizona Cardinals +7 at (474) San Francisco 49ers (o/u 48)
Date/Time: Sunday, September 13 at 4:25 p.m. EDT

It certainly has not been a smooth offseason for the 49ers. Wide receivers Jalen Hurd, Tavon Austin and J.J. Nelson have all been placed on the injured list, while Travis Benjamin opted out for this season. Rookie wideout Brandon Aiyuk and Deebo Samuel have both missed a large chunk of training camp with ailments. Running back Matt Breida is gone. Center Weston Richburg is still recovering from a knee injury, and his backup Ben Garland has not been practicing either.

Let’s put this line into a different perspective. Arizona was +10 at San Francisco in November of last year. San Francisco was riding as high as can be at 8-1 heading into that game. And there were fans in the stands. With no fans, no travel fatigue for Arizona and half of San Francisco’s offense on the injury report … you can still get +7 in this contest. Sounds pretty appealing, no?

A few trends, courtesy of The Gold Sheet:

  • Arizona went 5-10-1 straight-up last season, but went 10-5-1 against the spread.
  • Arizona went 6-1-1 against the spread on the road in 2019.
  • San Francisco went 3-4-1 against the spread at home last season.

San Francisco vs. Arizona Preview and Pick


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